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Background
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NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
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Background
References
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- Lu, L., et al., J. Clin. Endocrinol. Metab. 89(8):4113-4118 (2004).
- Castro-Obregon, S., et al., J. Biol. Chem. 279(17):17543-17553 (2004).
- Lin, B., et al., Cell 116(4):527-540 (2004).
- Choi, J.W., et al., Cancer Res. 64(1):35-39 (2004).
- Ye, X., et al., Int. J. Biochem. Cell Biol. 36(1):98-113 (2004).
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