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Background
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MAP2K5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation.
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Background
References
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- Cameron, S.J., et al., J. Biol. Chem. 279(2):1506-1512 (2004).
- Mehta, P.B., et al., Oncogene 22(9):1381-1389 (2003).
- Weldon, C.B., et al., Surgery 132(2):293-301 (2002).
- Dinev, D., et al., EMBO Rep. 2(9):829-834 (2001).
- Nicol, R.L., et al., EMBO J. 20(11):2757-2767 (2001).
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