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Background
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ATF2 is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components.
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Background
References
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- Kravets, A., et al., J. Biol. Chem. 279(19):19916-19923 (2004).
- Hong, S., et al., J. Biol. Chem. 279(17):16996-17003 (2004).
- Averous, J., et al., J. Biol. Chem. 279(7):5288-5297 (2004).
- Berger, A.J., et al., Cancer Res. 63(23):8103-8107 (2003).
- Wen-Sheng, W., Oncogene 22(7):955-963 (2003).
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