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Background
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BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It may play a role in the postsynaptic responses of hippocampal neuron. Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome), and a wide range of cancers such as lung cancer, non-Hodgkins lymphoma, and colorectal cancer.
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Background
References
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- Loewe, R., et al., J. Invest. Dermatol. 123(4):733-736 (2004).
- Yamaguchi, T., et al., J. Biol. Chem. 279(39):40419-40430 (2004).
- Frattini, M., et al., Oncogene 23(44):7436-7440 (2004).
- Tsavachidou, D., et al., Cancer Res. 64(16):5556-5559 (2004).
- Gear, H., et al., Invest. Ophthalmol. Vis. Sci. 45(8):2484-2488 (2004).
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