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Background
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NFKB1 is a 105 kD protein which can undergo co-translational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
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Background
References
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- Dephoure N, et al. (2008) Proc Natl Acad Sci U S A 105, 10762-7
- Cantin GT, et al. (2008) J Proteome Res 7, 1346-51
- Demarchi F, Bertoli C, Sandy P, Schneider C (2003) J Biol Chem 278, 39583-90
- Fujimoto K, Yasuda H, Sato Y, Yamamoto K (1995) Gene 165, 183-9
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List Price (USA): $235.00/0.1mg
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