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Background
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FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
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Background
References
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- Dowling,R.J., Cancer Res. 67 (22), 10804-10812 (2007)
- Bai,X., Science 318 (5852), 977-980 (2007)
- Zhou,J., Proc. Natl. Acad. Sci. U.S.A. 104 (41), 16158-16163 (2007)
- Radulovic,S., J BUON 12 SUPPL 1, S151-S162 (2007)
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List Price (USA): $235.00/0.1mg
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