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Background
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Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
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Background
References
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- Wang,Y., Circ. Res. 101 (6), 560-569 (2007)
- Fuchs,B.C., Am. J. Physiol., Cell Physiol. 293 (1), C55-C63 (2007)
- Olsen,J.V., Cell 127 (3), 635-648 (2006)
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