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Background
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NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. This protein is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). It is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response.
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Background
References
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- Golks,A., EMBO J. 26 (20), 4368-4379 (2007)
- Dong,X., J. Biol. Chem. 282 (41), 30303-30310 (2007)
- Gibson,H.M., J. Immunol. 179 (6), 3831-3840 (2007)
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