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Background
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E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
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Background
References
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- O'Donnell, K.A., et al., Nature 435(7043):839-843 (2005).
- Wang, C., et al., J. Biol. Chem. 280(13):12339-12343 (2005).
- Joshi, B., et al., Oncogene 24(13):2204-2217 (2005).
- Saberwal, G., et al., Int. J. Hematol. 80(2):146-154 (2004).
- Chaussepied, M., et al., Mol. Cell 16(5):831-837 (2004).
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