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Background
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SLAMF1 is a high-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
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Background
References
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- Mehrle,S., Mol. Immunol. 45 (3), 796-804 (2008)
- Howie,D., Blood 99 (3), 957-965 (2002)
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