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Background
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Protein S100-A11 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
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Background
References
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- Howell,M.D., J. Invest. Dermatol. 128 (9), 2248-2258 (2008)
- Cecil,D.L., J. Immunol. 180 (12), 8378-8385 (2008)
- Sakaguchi,M., J. Cell Biol. 163 (4), 825-835 (2003)
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