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Background
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The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
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Background
References
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- Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002).
- Kerb, R., et al., Pharmacogenomics 2(1):51-64 (2001).
- Cascorbi, I., et al., Clin. Pharmacol. Ther. 69(3):169-174 (2001).
- Hoffmeyer, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3473-3478 (2000).
- Mickley, L.A., et al., Blood 91(5):1749-1756 (1998).
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