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Background
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The membrane-associated protein ABCB9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in three known products which are likely to have different substrate specifications.
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Background
References
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- Kobayashi, A., et al., Biochem. Biophys. Res. Commun. 309(4):815-822 (2003).
- Zhang, F., et al., J. Biol. Chem. 275(30):23287-23294 (2000).
- Allikmets, R., et al., Hum. Mol. Genet. 5(10):1649-1655 (1996).
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