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Background
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
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Background
References
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- Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
- Basi, G., et al., J. Biol. Chem. 278(34):31512-31520 (2003).
- Barbiero, L., et al., Exp. Neurol. 182(2):335-345 (2003).
- Shi, X.P., et al., J. Biol. Chem. 278(23):21286-21294 (2003).
- Kondoh, K., et al., Breast Cancer Res. Treat. 78(1):37-44 (2003).
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