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Background
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BIRC4 is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
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Background
References
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- Srinivasula, S.M., et al., J. Biol. Chem. 278(34):31469-31472 (2003).
- Miranda, M.B., et al., Leukemia 17(2):390-400 (2003).
- Ahn, S.K., et al., Int. J. Mol. Med. 12(2):231-236 (2003).
- Yu, L.Y., et al., Mol. Cell. Neurosci. 22(3):308-318 (2003).
- Nomura, T., et al., Urol. Res. 31(1):37-44 (2003).
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