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Background
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BIRC7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
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Background
References
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- Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
- Gazzaniga, P., et al., Ann. Oncol. 14(1):85-90 (2003).
- Vucic, D., et al., J. Biol. Chem. 277(14):12275-12279 (2002).
- Sanna, M.G., et al., Mol. Cell. Biol. 22(6):1754-1766 (2002).
- Kasof, G.M., et al., J. Biol. Chem. 276(5):3238-3246 (2001).
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