|
Background
|
GREMLIN is a member of the BMP (bone morphogenic
protein) antagonist family. Like BMPs, BMP antagonists contain
cystine knots and typically form homo- and heterodimers. The CAN
(cerberus and dan) subfamily of BMP antagonists, to which this gene
belongs, is characterized by a C-terminal cystine knot with an
eight-membered ring. The antagonistic effect of the secreted
glycosylated protein encoded by this gene is likely due to its
direct binding to BMP proteins. As an antagonist of BMP, this gene
may play a role in regulating organogenesis, body patterning, and
tissue differentiation. In mouse, this protein has been shown to
relay the sonic hedgehog (SHH) signal from the polarizing region to
the apical ectodermal ridge during limb bud outgrowth.
|
Background
References
|
- Chen, B., et al., J. Immunol. 173(10):5914-5917 (2004).
- Chen, B., et al., Biochem. Biophys. Res. Commun. 295(5):1135-1141 (2002).
- McMahon, R., et al., J. Biol. Chem. 275(14):9901-9904 (2000).
- Murphy, M., et al., J. Biol. Chem. 274(9):5830-5834 (1999).
- Hsu, D.R., et al., Mol. Cell 1(5):673-683 (1998).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
