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Background
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The EDG2 integral membrane protein is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.
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Background
References
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- Matsuda, A., et al., Oncogene 22(21):3307-3318 (2003).
- Van Leeuwen, F.N., et al., J. Biol. Chem. 278(1):400-406 (2003).
- Shida, D., et al., Cancer Res. 63(7):1706-1711 (2003).
- Cervera, P., et al., Glia 38(2):126-136 (2002).
- An, S., et al., Mol. Pharmacol. 54(5):881-888 (1998).
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