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Background
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EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.
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Background
References
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- Hu, Y.L., et al., J. Natl. Cancer Inst. 95(10):733-740 (2003).
- Fujita, T., et al., Cancer Lett. 192(2):161-169 (2003).
- Contos, J.J., et al., Genomics 64(2):155-169 (2000).
- Zheng, Y., et al., FASEB J. 14(15):2387-2389 (2000).
- Young, K.W., et al., J. Biol. Chem. 275(49):38532-38539 (2000).
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