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Background
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The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus; a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region; and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs. Isoform II lacks ZNF1 and the PHD.
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Background
References
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- Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
- Hillier, L.W., et al., Nature 424(6945):157-164 (2003).
- Goo, Y.-H., et al., Mol. Cell. Biol. 23(1):140-149 (2003).
- Tan, Y.C., et al., Cancer Detect. Prev. 25(5):454-469 (2001).
- Nagase, T., et al., DNA Res. 7(2):143-150 (2000).
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