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Background
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OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
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Background
References
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- Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
- Sarkar, S.N., et al., J. Biol. Chem. 274(36):25535-25542 (1999).
- Ghosh, A., et al., J. Biol. Chem. 272(52):33220-33226 (1997).
- Ghosh, S.K., et al., J. Biol. Chem. 266(23):15293-15299 (1991).
- Rutherford, M.N., et al., EMBO J. 7(3):751-759 (1988).
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