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Background
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SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
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Background
References
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- Takata, T., et al., Biochem. Biophys. Res. Commun. 301(1):250-257 (2003).
- Bitterman, K.J., et al., J. Biol. Chem. 277(47):45099-45107 (2002).
- Langley, E., et al., EMBO J. 21(10):2383-2396 (2002).
- Frye, R.A., Biochem. Biophys. Res. Commun. 273(2):793-798 (2000).
- Frye, R.A., Biochem. Biophys. Res. Commun. 260(1):273-279 (1999).
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