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Background
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SIRT5 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
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Background
References
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- Frye, R.A., Biochem. Biophys. Res. Commun. 273(2):793-798 (2000).
- Frye, R.A., Biochem. Biophys. Res. Commun. 260(1):273-279 (1999).
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List Price (USA): $235.00/0.1mg
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