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Background
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HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. HES1 has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
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Background
References
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- Liu,J., Int. J. Gynecol. Cancer 17 (6), 1293-1299 (2007)
- Karlsson,C., J. Orthop. Res. 25 (2), 152-163 (2007)
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