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Background
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ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). ATF4 belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain.
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Background
References
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- Gombart,A.F., J. Leukoc. Biol. 81 (6), 1535-1547 (2007)
- Jousse,C., J. Biol. Chem. 282 (21), 15851-15861 (2007)
- Kakiuchi,C., Neurosci. Lett. 417 (3), 316-321 (2007)
- Marchand,A., J. Biol. Chem. 281 (28), 19124-19133 (2006)
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