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Background
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The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.
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Background
References
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- Orlandini, M., et al., J. Biol. Chem. 278(45):44650-44656 (2003).
- McColl, B.K., et al., J. Exp. Med. 198(6):863-868 (2003).
- Rissanen, T.T., et al., Circ. Res. 92(10):1098-1106 (2003).
- Nakamura, Y., et al., Clin. Cancer Res. 9(2):716-721 (2003).
- Yokoyama, Y., et al., Br. J. Cancer 88(2):237-244 (2003).
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List Price (USA): $235.00/0.1mg
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