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Background
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Amyloid b-peptide-binding alcohol dehydrogenase (ABAD) is a member of the family of short chain dehydrogenase/reductases; unique among this family, it binds amyloid b-peptide and exhibits enzymatic activity toward a wide variety of substrates including linear alcohols. In an amyloid beta-abundant environment, ABAD appears to trigger cell stress induced by the amyloid peptide.
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Background
References
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- FASEB J. 19 (6), 597-598 (2005)
- J. Mol. Biol. 342 (3), 943-952 (2004)
- Science 304 (5669), 448-452 (2004)
- FEBS Lett. 451 (3), 238-242 (1999)
- J. Biol. Chem. 274 (21), 15014-15019 (1999)
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