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Background
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Signal peptide peptidase (SPP) is an aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, SPP contains a critical GXGD motif in its C-terminal catalytic center. Several presenilin homologues/SPP-like proteins (PSHs/SPPL) have been identified. Unlike the ER localization of SPP and other SPPL proteins, SPPL2b is targeted through the secretory pathway to endosomes/lysosomes.
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Background
References
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- Friedmann, E., et al., J. Biol. Chem. 279(49):50790-50798 (2004).
- Grigorenko, A.P., et al., Biochemistry Mosc. 67(7):826-835 (2002).
- Weihofen, A., et al., Science 296(5576):2215-2218 (2002).
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