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Background
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Kallikreins are a group of serine proteases manifesting diverse physiological functions. The glandular kallikreins are a distinct group of serine proteases with an ability to release vasoactive peptides from kininogen in vitro, although the kininogenase activity of different kallikreins is highly variable. Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Many kallikrein genes are differentially expressed in various malignancies. Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer.
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Background
References
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- Haese, A., et al., J Urol. 2005 Mar;173(3):752-6.
- Chiang, C.H., et al., J Urol. 2005 Feb;173(2):429-32.
- Clements, J.A., et al., Crit Rev Clin Lab Sci. 2004;41(3):265-312.
- Borgono, C.A., et al., Mol Cancer Res. 2004 May;2(5):257-80.
- Yousef, G.M., Clin Biochem. 2003 Sep;36(6):443-52.
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