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Background
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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene for KLK10 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers.
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Background
References
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- Diamandis, E.P., et al., Clin. Biochem. 37(3):230-237 (2004).
- Sauter, E.R., et al., Int. J. Cancer 108(4):588-591 (2004).
- Petraki, C.D., et al., Prostate Cancer Prostatic Dis. 6(3):223-227 (2003).
- Luo, L.Y., et al., Br. J. Cancer 86(11):1790-1796 (2002).
- Bharaj, B.B., et al., Prostate 51(1):35-41 (2002).
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