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Background
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This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
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Background
References
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- Bahring, R., et al., J. Biol. Chem. 276(26):23888-23894 (2001).
- An, W.F., et al., Nature 403(6769):553-556 (2000).
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