|
Background
|
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
|
Background
References
|
- Galera,P., Proc. Natl. Acad. Sci. U.S.A. 91 (20), 9372-9376 (1994)
- Widom,R.L., Gene 198 (1-2), 407-420 (1997)
- Heegaard,A.M., J. Bone Miner. Res. 12 (12), 2050-2060 (1997)
- Widom,R.L., Matrix Biol. 20 (7), 451-462 (2001)
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
