|
Background
|
PARP1 is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
|
Background
References
|
- Tao,Z., Biochemistry 47 (21), 5804-5813 (2008)
- Gao,R., Mol. Cancer Ther. 7 (5), 1246-1250 (2008)
- Schreiber,V., EMBO J. 11 (9), 3263-3269 (1992)
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
