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Background
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SPP1 binds tightly to hydroxyapatite. The protein appears to form an integral part of the mineralized matrix and probably important to cell-matrix interaction. It acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
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Background
References
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- Macri,A., Tumori 95 (1), 48-52 (2009)
- Agnihotri,R., J. Biol. Chem. 276 (30), 28261-28267 (2001)
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