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Background
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PLZF is a member of the Krueppel C2H2-type zinc-finger protein family and a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL).
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Background
References
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- Shi,J., Int. J. Cancer 125 (7), 1558-1565 (2009)
- Doulatov,S., Genes Dev. 23 (17), 2076-2087 (2009)
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