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Background
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TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
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Background
References
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- Goldstein,A.S., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20882-20887 (2008)
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List Price (USA): $235.00/0.1mg
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