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Background
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Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
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Background
References
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- Kimura, M., et al., J. Biol. Chem. 274(11):7334-7340 (1999).
- Tseng, T.C., et al., DNA Cell Biol. 17(10):823-833 (1998).
- Bernard, M., et al., Genomics 53(3):406-409 (1998).
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