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Background
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The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
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Background
References
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- Calabrese, G., et al., Genomics 23(1):286-288 (1994).
- Parruti, G., et al., Biochem. Biophys. Res. Commun. 190(2):475-481 (1993).
- Benovic, J.L., et al., J. Biol. Chem. 266(23):14939-14946 (1991).
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