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Background
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AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).
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Background
References
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- Xu, Z., et al., Biochem. Biophys. Res. Commun. 312(2):388-396 (2003).
- Tiwari, G., et al., Mol. Cancer Res. 1(6):475-484 (2003).
- Brozinick, J.T. Jr., et al., Diabetes 52(4):935-941 (2003).
- Deregibus, M.C., et al., J. Biol. Chem. 277(28):25195-25202 (2002).
- Brodbeck, D., et al., J. Biol. Chem. 276(31):29550-29558 (2001).
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List Price (USA): $235.00/0.1mg
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