|
Background
|
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
|
Background
References
|
- Iida, S., et al., Oncogene 23(31):5266-5274 (2004).
- Yang, X., et al., Nat. Cell Biol. 6(7):609-617 (2004).
- Kamikubo, Y., et al., J. Biol. Chem. 278(20):17609-17614 (2003).
- Hisaoka, M., et al., Lab. Invest. 82(10):1427-1435 (2002).
- Hirota, T., et al., J. Cell Biol. 149(5):1073-1086 (2000).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
