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Background
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PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
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Background
References
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- Rosa, G., et al., Obes. Res. 11(2):176-182 (2003).
- Razeghi, P., et al., Cardiology 97(4):203-209 (2002).
- Rowles, J., et al., J. Biol. Chem. 271(37):22376-22382 (1996).
- Gudi, R., et al., J. Biol. Chem. 270(48):28989-28994 (1995).
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