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Background
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There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
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Background
References
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- Williams, J.M., et al., Mol. Microbiol. 27(1):171-186 (1998).
- Gress, T.M., et al., Oncogene 13(8):1819-1830 (1996).
- Kato, H., et al., Proc. Natl. Acad. Sci. U.S.A. 86(20):7861-7865 (1989).
- Tsutsumi, H., et al., Genomics 2(1):86-89 (1988).
- Tani, K., et al., Gene 73(2):509-516 (1988).
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