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Background
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N-acetylglucosamine kinase (NAGK) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals. The predicted 344-amino acid NAGK protein contains the 5 sequence motifs necessary for the binding of ATP by sugar kinases. NAGK shares 91.6% amino acid similarity with mouse Nagk, for which enzyme activity is detectable in all mouse tissues examined, with highest enzymatic activity in testis. It is hypothesized that NAGK has a general role in the catabolic pathways of GlcNAc as well as of ManNAc.
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Background
References
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- Hinderlich, S., et al., Eur. J. Biochem. 267(11):3301-3308 (2000).
- Lowes, W., et al., Biochim. Biophys. Acta 1379(1):134-142 (1998).
- Weidanz, J.A., et al., Br. J. Haematol. 95(4):645-653 (1996).
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