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Background
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The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
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Background
References
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- Picard, J.Y., et al., J. Soc. Biol. 196(3):217-221 (2002).
- Teixeira, J., et al., Endocr. Rev. 22(5):657-674 (2001).
- Imbeaud, S., et al., Nat. Genet. 11(4):382-388 (1995).
- Visser, J.A., et al., Biochem. Biophys. Res. Commun. 215(3):1029-1036 (1995).
- Sinisi, A.A., et al., J. Endocrinol. Invest. 26 (3 Suppl), 23-28 (2003).
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