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Background
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CDC42BPA is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization.
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Background
References
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- Dong, J.M., et al., Eur. J. Cell Biol. 81(4):231-242 (2002).
- Tan, I., et al., Mol. Cell. Biol. 21(8):2767-2778 (2001).
- Lam, L.T., et al., Hum. Mol. Genet. 9(14):2167-2173 (2000).
- Nakamura, N., et al., Genes Cells 5(7):571-581 (2000).
- Leung, T., et al., Mol. Cell. Biol. 18(1):130-140 (1998).
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