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Background
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NADP is essential for biosynthetic pathways, energy, and signal transduction. Its synthesis is catalyzed by NAD kinase, which phosphorylates NAD+ to form NADP+. The NAD kinase gene is expressed in most human tissues, but not in skeletal muscle. The catalytically active homotetramer is highly selective for its substrates, NAD and ATP.
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Background
References
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- Lerner, F., et al., Biochem. Biophys. Res. Commun. 288(1):69-74 (2001).
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