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Background
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Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death (apoptosis). DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
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Background
References
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- Shohat, G., et al., J. Biol. Chem. 276(50):47460-47467 (2001).
- Inbal, B., et al., Mol. Cell. Biol. 20(3):1044-1054 (2000).
- Deiss, L.P., et al., Genes Dev. 9(1):15-30 (1995).
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