|
Background
|
Plks (polo-like kinases) encode serine/threonine kinases that are closely
related to polo and CDC5, genes that are required for passage through mitosis
in Drosophila and Saccharomyces, respectively. Polo-like kinases, which
include Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk
(for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cell
proliferation. Plk protein accumulates in the cell during S and G2 phases of
the cell cycle, and both protein content and catalytic activity peak at the
onset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk are
immediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation.
|
Background
References
|
- Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
- Liby, K., et al., DNA Seq. 11:527-533 (2001).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
