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Background
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APPBP1 binds to the beta-amyloid precursor protein, a cell surface protein with signal-transducing properties thought to play a role in the pathogenesis of Alzheimer's disease. In addition, this protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. APPB1 is required for cell cycle progression through the S/M checkpoint.
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Background
References
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- Chen,Y., J. Cell Biol. 163 (1), 27-33 (2003)
- Chen,Y., J. Neurochem. 85 (3), 801-809 (2003)
- Walden,H., Nature 422 (6929), 330-334 (2003)
- Chow,N., J. Biol. Chem. 271 (19), 11339-11346 (1996)
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List Price (USA): $235.00/0.1mg
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