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Background
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ASK is a regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. It is required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
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Background
References
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- Nambiar,S.,Carcinogenesis 28 (12), 2501-2510 (2007)
- Tsuji,T.,Mol. Biol. Cell 17 (10), 4459-4472 (2006)
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List Price (USA): $235.00/0.1mg
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